Friday, October 14, 2011

Aspilet, Effectively Prevent Heart Disorders of Myocardial Infarction

Aspilet is one of the patent medicine names of Aspirin. Aspirin is included in the drug category of non-steroidal anti-inflammatory drug (NSAID). NSAID have anti-inflammatory, analgesic, antipyretic, and can inhibit thrombocyte aggregation.

Work mechanism of this drug is associated with inhibition of COX-1 activity, which plays for the major enzyme metabolism of arachidonic acid which is precursors of prostaglandins which play a major role in the pathogenesis of inflammation, pain and fever.

Reduction of prostaglandin (particularly E1) in central thermoregulation caused a decrease in body temperature due to expansion of blood vessels in the skin and sweat secretion increases. A good analgesic effect because it has a central effect and peripheral (edge).

Reduce thrombocyte aggregation, platelet adhesion and thrombus formation through suppression of thromboxane A2 synthesis in thrombocyte. Reducing the risk of myocardial infarction in unstable stenocardia.

These drugs are effective for primary prevention of cardiovascular disease and secondary prevention of myocardial infarction.

This drug can increase the fibrinolytic activity and reduced plasma concentrations of vitamin K in coagulation factors (II, VII, IX, X). Increasing the level of bleeding complications in the implementation of surgical procedures.

Blockade of COX-1 in gastric mucosa may lead to inhibition of gastroprotective prostaglandins, which may cause ulceration of the mucous membranes.

Composition
Containing acetylsalicylic acid

Indications
  1. Rheumatoid arthritis
  2. Fever during infectious and inflammatory diseases
  3. To overcome the pain
  4. Neuralgia
  5. Myalgia
  6. Headache
  7. Primary and secondary prevention of myocardial infarction

Contraindications
  1. Patients who are sensitive to aspirin
  2. Asthma
  3. Peptic ulcers
  4. Subcutaneous bleeding
  5. Hemophilia
  6. Thrombocytopenia
  7. Patients with anticoagulant therapy

Doses
For the dose by mouth (orally) depending on the indication of its use, for example:
1. For antipyretics (fever reducing) and analgesic (pain reliever)
Adults: 3 x 500-1000 mg / day
2. Primary and secondary prevention of myocardial infarction
1 x 40-325 mg / day (usually 160 mg)
3. As an inhibitor of thrombocyte aggregation
300-325 mg / day

Side effects
1. Digestive system
Nausea, vomiting, anorexia, epigastric pain, diarrhea, erosive and ulcerative wounds.

2. Central nervous system
Long-term use may cause dizziness, headache, reversible visual disturbances, tinnitus, and aseptic meningitis.

3. Hemopoietic system:
Thrombocytopenia and anemia, but it rarely happens.

4. Clotting system
The extension of bleeding time.

5. Urinary system:
In the long-term use can cause renal dysfunction, acute renal failure, nephrotic syndrome, but rarely happens.

6. Allergic reactions
Skin rash, edema, bronchospasm, "aspirin triad" (a combination of bronchial asthma, recurrent nasal polyposis, paranasal sinuses, acetylsalicylic acid intolerance, and medicine series pirazolonic).

7. Other side effects
In some cases it can cause Reye's syndrome and the long-term use can improve the symptoms of chronic heart failure.

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